Metal binding in superantigens
نویسندگان
چکیده
منابع مشابه
Endogenous superantigens shape response to exogenous superantigens.
Endogenous superantigen-mediated thymic negative selection resulted in a paucity of mature T cells bearing T-cell receptor (TCR) Vbeta8 in the periphery. Consequently, the magnitude of immune response to exogenous superantigen staphylococcal enterotoxin B, which activates TCR Vbeta8(+) T cells, was significantly reduced and conferred protection from superantigen-induced mortality.
متن کاملA Review on Superantigens
Superantigens are microbial products which are immunostimulatory and disease causing. They stimulate a large fraction of T cells unlike conventional antigens. These superantigens include various staphylococcal enterotoxins, streptococcal toxic shock syndrome toxins, viral proteins etc. The superantigen family comprise of proteins that range from 22-29 kDa in size and highly resistant to proteas...
متن کاملStaphylococcal enterotoxin microbial superantigens.
Staphylococcal enterotoxins are a family of structurally related proteins that are produced by Staphylococcus aureus. In addition to their role in the pathogenicity of food poisoning, these microbial superantigens have profound effects on the immune system, which makes them useful tools for understanding its mechanism of action. These molecules (24-30 kDa) are highly hydrophilic and exhibit low...
متن کاملMetal-binding mechanisms in metallothioneins.
Metallothionein are small, cysteine-rich, metal-binding proteins that are found ubiquitously in nature. Most metallothioneins bind multiple metals in two well-defined metal-thiolate clusters. This perspective discusses the use of optical spectroscopy to study the metalation of metallothioneins and the emergence of electrospray ionization mass spectrometry as a means of studying the mechanism of...
متن کاملMetal Binding Sites in Proteins
Metal ions play a critical role in living systems. About one third of proteins need to bind metal for their stability and/or function. In this review, current sequence based and structure based methods for metal binding site prediction will be presented, with emphasis on the CHED and SeqCHED methods of prediction from apo-protein structures and protein sequences having homologs (even remote) in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 1996
ISSN: 0108-7673
DOI: 10.1107/s0108767396090423